RGR
retinal G protein coupled receptor
- Ensembl:
- ENSG00000148604
- UniProt:
- P47804
- OMIM:
- 600342
- Synonyms:
- RP44
Cilia effects upon perturbation of RGR
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.57) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=313, lfc=-2.39) PMID:30270045
Phenotypes
- Human ciliopathy phenotype:
- retinitis pigmentosa
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Mutations in the RGR gene cause Retinitis Pigmentosa (PMID: 10581022, 21067480).