RGS5

regulator of G protein signaling 5

Ensembl:: ENSG00000143248
UniProt:: O15539
OMIM:: 603276

Cilia effects upon perturbation of RGS5

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.86) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)

Function

RGS5 is an endogenous regulator of Hh-mediated sig ling and that RGS proteins are potential targets for novel therapeutics in Hh-mediated diseases(PMID: 23637832).

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