RGS8

regulator of G protein signaling 8

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000135824
UniProt:
P57771
OMIM:
607189
Synonyms:
MGC119067, MGC119068, MGC119069

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.72) PMID:41160700

Phenotypes

Mouse phenotype:
hyperactivity

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:29758252

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MCHR1-positive primary cilia are significantly elongated in the CA1 of RGS8tg, compared with that in wild mice. Depression-like behavior in RGS8tg might result through RGS8-ciliary MCHR1 interaction in the CA1 region ( 29758252).