RIC8B
RIC8 guanine nucleotide exchange factor B
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000111785
- UniProt:
- Q9NVN3
- OMIM:
- 609147
- Synonyms:
- HSyn, Synembryn-B, Brain Synembryn, Chaperone Ric-8B, FLJ10620, RIC8
Cilia effects upon perturbation of RIC8B
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Impaired ciliogenesis
- Overexpression effect:
- Unknown
Phenotypes
- Mouse phenotype:
- embryonic lethal (RIC-8B knockout)
Subcellular localization
cilia, centrosome, cytosol, plasma membrane
References: PMID:37910589
Functional category
- G protein signaling
- Cilium signaling
- Ciliary assembly/disassembly
- Cilia–cytoskeleton/adhesion links
Function
RIC8 paralog of RIC8A. Acts as a guanine nucleotide exchange factor and chaperone for Galpha-s and Galpha-olf subunits. Subcellular localization includes centrosome, cytosol, and plasma membrane (UniProt). C. elegans has a single ric-8 gene whose ortholog functions overlap both mammalian paralogs. Campagna et al. 2026 reported that human RIC8B (alongside RIC8A) is required for ciliogenesis in RPE-1 cells (preprint figures pending direct review). Mouse Ric8b knockout is embryonic lethal.