RILPL1

Cilia effects upon perturbation of RILPL1

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.24) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased startle reflex, increased fasting circulating glucose level

Subcellular localization

basal body, centrosome, cilia, cytosol, nucleus

References: PMID:41005307, PMID:23264467, PMID:29125462, PMID:30398148

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Ciliary membrane

Function

Rab effector-related protein, regulates protein concentration by removal of membrane proteins from the cilium. Depletion results in accumulation of signaling proteins in the ciliary membrane, including Smo. Interacts with activated Rab34, Rab36, Rab12 and Rab40B (23264467). Interacts with the LRRK2- phosphorylated forms of Rab8A and Rab10 (29125462). Enhances pRab10 clustering on pericentriolar membranes to suppress ciliogenesis (30398148).