RILPL2

Rab interacting lysosomal protein like 2

Ensembl:
ENSG00000150977
UniProt:
Q969X0
OMIM:
614093
Synonyms:
FLJ30380, FLJ32372, MGC7036

Cilia effects upon perturbation of RILPL2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.85) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased fasting circulating glucose level, decreased circulating cholesterol level
Mouse ciliopathy phenotype:
increased heart weight

Subcellular localization

centrosome, cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Ciliary membrane

Function

Rab effector-related protein that exhibist dy mic localisation, regulates protein concentration by removal of membrane proteins from the cilium.. Depletion results in accumulation of sig ling proteins in the ciliary membrane, including Smo. Interacts with activated Rab34 and Rab36 (23264467). Binds to phosphorylated Rab8A, Rab10, and Rab12. As it binds Rab8a much stronger than RILPL1, RILPL2 might be a key effector specific for pRab8A (29125462).

Model organism evidence

Mus musculus (2 references)

Affinity enrichment mass spectrometry revealed that the primary ciliogenesis regulator, RILPL1 specifically interacts with the LRRK2-phosphorylated forms of Rab8A and Rab10, whereas RILPL2 binds to phosphorylated Rab8A, Rab10, and Rab12.

The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content.

PMIDs: 29125462, 23264467