RILPL2

Rab interacting lysosomal protein like 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000150977
UniProt:: Q969X0
OMIM:: 614093
Synonyms:: FLJ30380, FLJ32372, MGC7036

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.85) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased fasting circulating glucose level, decreased circulating cholesterol level

Subcellular localization

centrosome, cilia

References: PMID:41005307, PMID:23264467, PMID:29125462

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Ciliary membrane

Function

Rab effector-related protein that exhibist dynamic localisation, regulates protein concentration by removal of membrane proteins from the cilium.. Depletion results in accumulation of signaling proteins in the ciliary membrane, including Smo. Interacts with activated Rab34 and Rab36 (23264467). Binds to phosphorylated Rab8A, Rab10, and Rab12. As it binds Rab8a much stronger than RILPL1, RILPL2 might be a key effector specific for pRab8A (29125462).

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