RLBP1

retinaldehyde binding protein 1

Ensembl:
ENSG00000140522
UniProt:
P12271
OMIM:
180090
Synonyms:
CRALBP

Cilia effects upon perturbation of RLBP1

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.10) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.28) PMID:41160700

Phenotypes

Mouse phenotype:
increased lean body mass; abnormal tooth morphology
Human ciliopathy phenotype:
Newfoundland cone-rod dystrophy; retinitis pigmentosa

Ciliopathy associations

  • Retinal Dystrophy/Degeneration

Subcellular localization

centrosome, cilia associated gene, cytosol, nucleoplasm

Function

Reporter activity of wildtype and mutant RLBP1 promoter constructs suggest that CRALBP transcriptional regulation may be similar in the ciliary epithelium (CE) and retinal pigment epithelium (RPE) but different in Müller cells(PMID: 12565814).