RMND5A

required for meiotic nuclear division 5 homolog A

Ensembl:
ENSG00000153561
UniProt:
Q9H871
OMIM:
618964
Synonyms:
FLJ13910, GID2, GID2A, P44CTLH, RMD5

Cilia effects upon perturbation of RMND5A

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.48) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly

Function

RMND5A and TWA1 are present at the basal body, at the axoneme in primary cilia and motile mono-cilia, and at the centrioles in cycling cells, and other integral components of the GID complex(ARMC8 and MKLN1) are present at the axoneme in primary cilia, suggesting that the GID complex has a function at the primary cilium(35543155).