RNF34

ring finger protein 34

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000170633
UniProt:
Q969K3
OMIM:
608299
Synonyms:
FLJ21786, RIF, RIFF

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.04, ciliated=22.0%) PMID:26595381

Phenotypes

Mouse phenotype:
abnormal coat/hair pigmentation, abnormal lymph node morphology, abnormal skin morphology, abnormal skin coloration, improved glucose tolerance, abnormal lung morphology, abnormal eye morphology, enlarged lung, abnormal thymus morphology, anophthalmia, enlarged lymph nodes, enlarged thymus, decreased heart rate

Subcellular localization

basal body, nucleus

References: PMID:35170427

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

UBE2E1 underwent auto-ubiquitination and that ubiquitination was enhanced but not dependent on RNF34 (35170427).