RNF34

ring finger protein 34

Ensembl:
ENSG00000170633
UniProt:
Q969K3
OMIM:
608299
Synonyms:
FLJ21786, RIF, RIFF

Cilia effects upon perturbation of RNF34

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.04, ciliated=22.0%) PMID:26595381

Phenotypes

Mouse phenotype:
abnormal coat/hair pigmentation, abnormal lymph node morphology, abnormal skin morphology, abnormal skin coloration, improved glucose tolerance, abnormal lung morphology, abnormal eye morphology, enlarged lung, abnormal thymus morphology, anophthalmia, enlarged lymph nodes, enlarged thymus, decreased heart rate
Mouse ciliopathy phenotype:
abnormal heart morphology, enlarged heart

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

UBE2E1 underwent auto-ubiquiti tion and that ubiquiti tion was enhanced but not dependent on RNF34 (35170427).

Model organism evidence

Mus musculus (1 reference)

Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1.

PMIDs: 35170427