ROPN1B
rhophilin associated tail protein 1B
- Ensembl:
- ENSG00000114547
- UniProt:
- Q9BZX4
Cilia effects upon perturbation of ROPN1B
Ciliogenesis screen results (1 screen)
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
flagella
Functional category
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- T cell biology
- Reproduction & sperm
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
Function
ROPN1B has localized in flagella.
Model organism evidence
Mus musculus (2 references)
The fibrous sheath (FS) is a flagellar cytoskeletal structure unique to sperm that surrounds the outer dense fibers and axoneme.
ASP and ROPN1 are 41% identical in sequence, interact with a variety of AKAPs in a manner similar to PKA, and are expressed in ciliated and flagellated human cells.