ROPN1L

rhophilin associated tail protein 1 like

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000145491
UniProt:
Q96C74
OMIM:
611756
Synonyms:
ASP, FLJ25776, LINC01513, RP11-1C1.7, RSPH11, TCONS_00009352

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.51) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased grip strength, abnormal snout morphology, abnormal tooth morphology

Ciliopathy associations

  • Male Infertility

References: PMID:35207567

Subcellular localization

cilia, transition zone

References: PMID:41005307, PMID:22021175

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion

Function

Functions as a key molecule in the maintenance of basal ciliary beat frequency. Its role in ciliary motility coulb be played via regulation of axonemal signaling (22021175)