ROPN1L
rhophilin associated tail protein 1 like
- Ensembl:
- ENSG00000145491
- UniProt:
- Q96C74
- OMIM:
- 611756
- Synonyms:
- ASP, FLJ25776, LINC01513, RP11-1C1.7, RSPH11
Cilia effects upon perturbation of ROPN1L
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.51) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- decreased grip strength, abnormal snout morphology, abnormal tooth morphology
- Mouse ciliopathy phenotype:
- kyphosis, abnormal spine curvature
Ciliopathy associations
- Male Infertility
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Reproduction & sperm
- Protein processing & maturation
- Cell migration & adhesion
Function
Functions as a key molecule in the mainte nce of basal ciliary beat frequency. Its role in ciliary motility coulb be played via regulation of axonemal sig ling (22021175)
Model organism evidence
Mus musculus (2 references)
Loss of NSUN7 altered the abundance of proteins essential for dynein arm assembly (PIH1D3, CCDC103, CCDC40), intraflagellar transport (IFT122), and fibrous sheath organization (AKAP3, AKAP4, ROPN1L).
The fibrous sheath (FS) is a flagellar cytoskeletal structure unique to sperm that surrounds the outer dense fibers and axoneme.