RPAP3

RNA polymerase II associated protein 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000005175
UniProt:: Q9H6T3
OMIM:: 611477
Synonyms:: FLJ21908, HSPAGH, SPAG, TAH1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.37) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased circulating phosphate level, enlarged thymus, embryonic lethality prior to organogenesis, abnormal thymus morphology, preweaning lethality, complete penetrance, decreased circulating glucose level

Subcellular localization

basal body, ciliary tip, cilia

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Protein processing & maturation

Function

RPAP3 has localized in basal body.

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