RPL10A

ribosomal protein L10a

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000198755
UniProt:: P62906
OMIM:: 615660
Synonyms:: CSA-19, L10A, NEDD6, UL1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.10) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, nucleus

References: PMID:34848703, PMID:42105234

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

Rpl10a, Rpl11, and Rps3 were detected as puncta in ependymal multicilia (34848703) Immunostaining confirms ribosome components and translation factors in primary cilia of embryonic radial glia (RPS23, RPL19, EIF3C, EEF2, EEF1G; RPL23A at the ciliary base) and in NIH3T3 cilia (RPS3, RPL11, RPL10A) (Liu et al., 2026, Cell Rep, PMID 42105234).

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