RPL19

ribosomal protein L19

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000108298
UniProt:
P84098
OMIM:
180466
Synonyms:
DKFZP779D216, EL19, FLJ27452, L19, MGC71997

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.37, ciliated=55.8%) PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

cilia, cytosol, nucleus

References: PMID:42105234

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Multiple components of translation machinery are present in the cilia of RG, including ribosome components, RPS23 and RPL19, and translation factors, EIF3C, EEF2 and EEF1G. Immunostaining confirms ribosome components and translation factors in primary cilia of embryonic radial glia (RPS23, RPL19, EIF3C, EEF2, EEF1G; RPL23A at the ciliary base) and in NIH3T3 cilia (RPS3, RPL11, RPL10A) (Liu et al., 2026, Cell Rep, PMID 42105234).