RPS23

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.61) PMID:26167766
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:

brachycephaly, trichomegaly, and developmental delay

Subcellular localization

cilia, cytosol, nucleus

References: PMID:42105234

Functional category

• Ciliary assembly/disassembly
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Multiple components of translation machinery are present in the cilia of RG, including ribosome components, RPS23 and RPL19, and translation factors, EIF3C, EEF2 and EEF1G. Immunostaining confirms ribosome components and translation factors in primary cilia of embryonic radial glia (RPS23, RPL19, EIF3C, EEF2, EEF1G; RPL23A at the ciliary base) and in NIH3T3 cilia (RPS3, RPL11, RPL10A) (Liu et al., 2026, Cell Rep, PMID 42105234).