RPS3
ribosomal protein S3
- Ensembl:
- ENSG00000149273
- UniProt:
- P23396
- OMIM:
- 600454
- Synonyms:
- FLJ26283, FLJ27450, MGC87870, S3, US3
Cilia effects upon perturbation of RPS3
Ciliogenesis screen results (5 screens)
- Kim2016: Increased cilia numbers
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.68) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=4.25, ciliated=70.2%) PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=884, lfc=-3.39) PMID:30270045
Subcellular localization
cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Viral interactions
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
Rpl10a, Rpl11, and Rps3 were detected as puncta in ependymal multicilia (34848703)