RPS3

ribosomal protein S3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000149273
UniProt:
P23396
OMIM:
600454
Synonyms:
FLJ26283, FLJ27450, MGC87870, S3, US3

Ciliogenesis screen results (5 screens)

  • Kim2016: Increased cilia numbers
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.68) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=4.25, ciliated=70.2%) PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=884, lfc=-3.39) PMID:30270045

Subcellular localization

cilia, cytosol, nucleus

References: PMID:34848703, PMID:42105234

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Rpl10a, Rpl11, and Rps3 were detected as puncta in ependymal multicilia (34848703) Immunostaining confirms ribosome components and translation factors in primary cilia of embryonic radial glia (RPS23, RPL19, EIF3C, EEF2, EEF1G; RPL23A at the ciliary base) and in NIH3T3 cilia (RPS3, RPL11, RPL10A) (Liu et al., 2026, Cell Rep, PMID 42105234).