RPS6KA1

ribosomal protein S6 kinase A1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000281877
UniProt:: Q15418
OMIM:: 601684
Synonyms:: HU-1, MAPKAPK1, P90RSK, RSK1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.40) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.94) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased startle reflex

Subcellular localization

basal body, cytosol, nucleus

References: PMID:23264740

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

p90RSK (RPS6KA1-p90) is activated downstream of the MEK1/2–ERK1/2 pathway after PDGFRαα signaling in the primary cilium, which results in activation of p90RSK at the ciliary base (23264740).

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