RRAD

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

Ensembl:
ENSG00000166592
UniProt:
P55042
OMIM:
179503
Synonyms:
RAD, REM3

Cilia effects upon perturbation of RRAD

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.90, ciliated=59.8%) PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=644, lfc=0.64) PMID:30270045

Phenotypes

Mouse phenotype:
shortened st segment, shortened rr interval, increased circulating alkaline phosphatase level, increased heart rate, increased mean corpuscular hemoglobin, increased circulating potassium level
Mouse ciliopathy phenotype:
increased heart weight

Subcellular localization

basal body, flagella

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

RRAD has localized in basal body,flagella.