RSPH6A

radial spoke head 6 homolog A

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000104941
UniProt:: Q9H0K4
OMIM:: 607548
Synonyms:: RSHL1, RSP4, RSP6, RSPH4B

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:30185526, PMID:30239614

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

RSPH6A is required for sperm flagellar assembly and male fertility in mice. Interacts with RSPH1, RSPH4A, RSPH9 and RSPH10B, where nteraction of RSPH6A and RSPH9 is important to incorporate RSPH9 into the flagella. Absence of RSPH6A leads to immotile spermatozoa in mice (30185526). Expressed exclusively in testicular germ cells during meiosis. Rsph6a is phosphorylated by PKA during sperm capacitation (30239614).

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