RUNX1

RUNX family transcription factor 1

Ensembl:
ENSG00000159216
UniProt:
Q01196
OMIM:
151385
Synonyms:
AML1, AMLCR1, CBFA2, PEBP2A2

Cilia effects upon perturbation of RUNX1

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.85) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=417, lfc=0.66) PMID:30270045

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Expression level of hematopoietic stem and progenitor cell marker, runx1, decreased in cilia-impaired embryos(31015398).