RXRG

retinoid X receptor gamma

Ensembl:: ENSG00000143171
UniProt:: P48443
OMIM:: 180247
Synonyms:: NR2B3, RXR-GAMMA, RXRGAMMA

Cilia effects upon perturbation of RXRG

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased circulating HDL cholesterol level; decreased grip strength; increased circulating cholesterol level; increased circulating triglyceride level; decreased thermal nociceptive threshold; abnormal bone mineralization

Subcellular localization

nuclear bodies, nucleoplasm

Functional category

Motile cilium & axoneme

Function

Mutations in RXRG cause Simpson-Golabi-Behmel Syndrome (PMID: 36936145).

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