S100A4

S100 calcium binding protein A4

Ensembl:
ENSG00000196154
UniProt:
P26447
OMIM:
114210
Synonyms:
18A2, 42A, CAPL, FSP1, MTS1

Cilia effects upon perturbation of S100A4

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-13.78) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

MST1/2 has a noncanonical function: regulation of microtubule stability/dy mics. Loss of MST1/2 or its target(s) NDR1/2 destabilizes kinetochore-microtubule attachment during mitosis (20171103 , 19327996). MST1/2 binds and phosphorylates AURKA, leading to dissociation of the AURKA/HDAC6 cilia-disassembly complex, and MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes . MST1 is activated during ciliogenesis and localizes to the basal body of cilia. (25367221).