SAG

S-antigen visual arrestin

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000281857
UniProt:
P10523
OMIM:
181031
Synonyms:
ARRESTIN, RP47

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased lean body mass, decreased circulating fructosamine level, iris synechia, decreased total body fat amount, decreased circulating hdl cholesterol level

Subcellular localization

cytosol, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mutations in the SAG gene cause Retinitis Pigmentosa (PMID: 9565049).