SAG
S-antigen visual arrestin
- Ensembl:
- ENSG00000281857
- UniProt:
- P10523
- OMIM:
- 181031
- Synonyms:
- ARRESTIN, RP47
Cilia effects upon perturbation of SAG
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- increased lean body mass, decreased circulating fructosamine level, iris synechia, decreased total body fat amount, decreased circulating hdl cholesterol level
- Mouse ciliopathy phenotype:
- decreased circulating calcium level
Subcellular localization
cilia associated gene, cytosol, microtubules
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Mutations in the SAG gene cause Retinitis Pigmentosa (PMID: 9565049).
Model organism evidence
Mus musculus (3 references)
Intraflagellar transport (IFT) drives the bidirectional movement of trains composed of IFT-A, IFT-B, and BBSome complexes that build and maintain cilia while supporting their signaling functions.
Rescue experiments employed the Smoothened agonist (SAG) to activate Shh signaling.Main Outcome MeasureCilia incidence and length; Smo/Gli3 mRNA and protein expression; Gli3A/Gli3R ratio; cell proliferation rates (OD values, PCNA, Cyclin D1); SAG-mediated rescue effects.ResultsIntraflagellar tra