SALL1

spalt like transcription factor 1

Ensembl:
ENSG00000103449
UniProt:
Q9NSC2
OMIM:
602218
Synonyms:
HSAL1, TBS, ZNF794

Cilia effects upon perturbation of SALL1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Townes-Brocks Syndrome

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Cardiac & muscle development
  • Transcription regulation

Function

Zinc-finger transcription factor that mediates transcriptio l repression via its interaction with the nucleosome- remodeling deacetylase (NuRD) complex. Truncated SALL1 interacts with or sequester factors related to cilia function, including the negative regulators of ciliogenesis CCP110 and CEP97. SALL1 mutations can disrupt cilia formation and function (29395072). Truncated SALL1 increases the ubiquitin proteasome- mediated degradation of LUZP1, contributing to Townes-Brocks Syndrome (32553112).