SATB2

SATB homeobox 2

Ensembl:
ENSG00000119042
UniProt:
Q9UPW6
Synonyms:
FLJ21474, KIAA1034

Cilia effects upon perturbation of SATB2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, enlarged lymph nodes, abnormal craniofacial morphology, increased mean corpuscular volume, increased circulating alkaline phosphatase level
Mouse ciliopathy phenotype:
abnormal uterus morphology, abnormal reti morphology
Human ciliopathy phenotype:
Intellectual disability

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • ECM & connective tissue
  • Transcription regulation

Function

SATB2 has localized in basal body.