SAXO2

stabilizer of axonemal microtubules 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000188659
UniProt:: Q658L1
Synonyms:: FAM154B, DKFZP666G057

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

centrosome, cilia, connecting piece, cytosol, mid piece

References: PMID:41410385, PMID:42010243, PMID:40421755

Functional category

Metabolism
Cilia–cytoskeleton/adhesion links

Function

Four SAXO proteins (SAXO1-SAXO4) are investigated in Chlamydomonas reinhardtii, identified via bioinformatics. All localize to cilia but differ in axonemal binding and spatial distribution. Single SAXO knockouts had no effect, whereas double mutants (saxo1/2, saxo1/3 and saxo2/3) showed shorter cilia. This phenotype intensified in the saxo1/2/3 triple mutant but not further in the quadruple mutant. Ciliary beating remained normal in saxo1/2/3 mutants, even under mechanical stress, indicating that SAXO1-SAXO3 are not essential for ciliary rigidity(PMID: 40421755).SAXO2 has located to motile cilia.

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.