SAXO2

stabilizer of axonemal microtubules 2

Ensembl:
ENSG00000188659
UniProt:
Q658L1
Synonyms:
FAM154B, DKFZP666G057

Cilia effects upon perturbation of SAXO2

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

centrosome, cilia, connecting piece, cytosol, mid piece

Functional category

  • Metabolism
  • Cilia–cytoskeleton/adhesion links

Function

Four SAXO proteins (SAXO1-SAXO4) are investigated in Chlamydomonas reinhardtii, identified via bioinformatics. All localize to cilia but differ in axonemal binding and spatial distribution. Single SAXO knockouts had no effect, whereas double mutants (saxo1/2, saxo1/3 and saxo2/3) showed shorter cilia. This phenotype intensified in the saxo1/2/3 triple mutant but not further in the quadruple mutant. Ciliary beating remained normal in saxo1/2/3 mutants, even under mechanical stress, indicating that SAXO1-SAXO3 are not essential for ciliary rigidity(PMID: 40421755).SAXO2 has located to motile cilia.

Model organism evidence

Mus musculus (1 reference)

Furthermore, we found that Ankef1a, Odf3l2a, and Saxo2 exhibit distinct localization patterns along the length of the kinocilium and within the cell body.

PMIDs: 37367482

Danio rerio (1 reference)

Furthermore, we found that Ankef1a, Odf3l2a, and Saxo2 exhibit distinct localization patterns along the length of the kinocilium and within the cell body.

PMIDs: 37367482