SAXO3

stabilizer of axonemal microtubules 3

Ensembl:: ENSG00000268655
UniProt:: A0A1B0GTJ6

Cilia effects upon perturbation of SAXO3

Subcellular localization

cilia

Functional category

Cilia–cytoskeleton/adhesion links

Function

Four SAXO proteins (SAXO1-SAXO4) are investigated in Chlamydomonas reinhardtii, identified via bioinformatics. All localize to cilia but differ in axonemal binding and spatial distribution. Single SAXO knockouts had no effect, whereas double mutants (saxo1/2, saxo1/3 and saxo2/3) showed shorter cilia. This phenotype intensified in the saxo1/2/3 triple mutant but not further in the quadruple mutant. Ciliary beating remained normal in saxo1/2/3 mutants, even under mechanical stress, indicating that SAXO1-SAXO3 are not essential for ciliary rigidity(PMID: 40421755)

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