SCAMP2

secretory carrier membrane protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000140497
UniProt:
O15127
OMIM:
606912

Ciliogenesis screen results (6 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.61) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=795, lfc=0.71) PMID:30270045
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.46) PMID:20393562

Phenotypes

Mouse phenotype:
abnormal startle reflex, decreased startle reflex, decreased fasting circulating glucose level, increased circulating total protein level, sclerocornea, decreased grip strength

Subcellular localization

endosome, flagella, nucleus

References: PMID:25613900

Function

SCAMP2 has localized in flagella.