SCG5

Cilia effects upon perturbation of SCG5

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=0.00) PMID:37771269

Phenotypes

Mouse phenotype:

abnormal behavior, increased monocyte cell number, increased circulating alkaline phosphatase level, decreased thigmotaxis, hyperactivity, decreased anxiety-related response, increased lean body mass

Mouse ciliopathy phenotype:

abnormal reti vasculature morphology

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Protein processing & maturation

Function

SCG5 one of the Foxj1-induced genes (FIGs), direct and indirect targets of Foxj1, are localized to cilia in the zebrafish embryo(25139857).