SCN10A

sodium voltage-gated channel alpha subunit 10

Ensembl:
ENSG00000185313
UniProt:
Q9Y5Y9
OMIM:
604427
Synonyms:
HPN3, NAV1.8, PN3, SNS

Cilia effects upon perturbation of SCN10A

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.66) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, flagella

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

SCN10A has localized in basal body,flagella.