SCN2A

sodium voltage-gated channel alpha subunit 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000136531
OMIM:: 182390
Synonyms:: HBSCI, HBSCII, NAV1.2, SCN2A1, SCN2A2

Subcellular localization

cilia

References: PMID:39677731

Functional category

RTK/FGF signaling
Signaling (Hedgehog
GPCRs
ion channels)

Function

Human GFP-tagged constructs for SLC6A1, SYNGAP1, PSD95, and SCN2A (green) localize to primary cilia (cilia labeled by Flag-tagged Dopamine D1 receptor, magenta, basal bodies labeled by FGFR1OP, red) when expressed in primary rat striatal neurons. (C) Endogenous staining for SLC6A1, SYNGAP1, PSD95, and SCN2A in primary cilia (labeled by ARL13B, magenta, basal bodies labeled by FGFR1OP, red) in primary rat striatal neurons(39677731). Antibody staining in rat brain cells confirms ciliary localization of SCN2A (Kostyanovskaya et al., 2025, bioRxiv, PMID 39677731).

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