SCNN1G

sodium channel epithelial 1 subunit gamma

Ensembl:
ENSG00000166828
UniProt:
P51170
OMIM:
600761
Synonyms:
ENACGAMMA, SCNEG

Cilia effects upon perturbation of SCNN1G

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
bronchiectasis with or without elevated sweat chloride 3; Bronchiectasis

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

SCNN1G has localized in primary cilia.