SCYL1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000142186
UniProt:: Q96KG9
OMIM:: 607982
Synonyms:: GKLP, NKTL, NTKL, P105, TAPK, TEIF, TRAP, HT019, SCAR21, MGC78454

Cilia effects upon perturbation of SCYL1

Loss-of-function effect:: Shorter cilia

Subcellular localization

Golgi apparatus, cytosol

References: doi:10.64898/2026.06.09.731172

Function

SCY1-like pseudokinase 1; catalytically inactive kinase regulating COPI-mediated retrograde Golgi-ER protein trafficking and Golgi morphology, and a transcriptional regulator of TERT/POLB. Cilia-associated on functional grounds (Lee et al. 2026): key driver of a convergent ciliary transcriptional program downstream of schizophrenia common-risk genes; CRISPR perturbation in mouse neocortical cells significantly decreased primary cilia length. Mutations cause CALFAN/SCAR21 syndrome (low-GGT cholestasis/liver failure, cerebellar atrophy, ataxia, peripheral neuropathy). Golgi/cytosolic, not ciliary-localizing; ciliary link is functional (cilia-length phenotype).

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