SEMA3A

semaphorin 3A

Ensembl:
ENSG00000075213
UniProt:
Q14563
Synonyms:
COLL-1, HSEMA-I, SEMA1, SEMAD, SEMD

Cilia effects upon perturbation of SEMA3A

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.55) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.59) PMID:41160700

Ciliopathy associations

  • Kallmann Syndrome

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Axon guidance & growth

Function

The loss of AC3 activity in β3GnT2−/− mice leads to a misregulation of both Nrp1 and Sema3A expression. AC3-dependent cAMP regulates the expression of the axon guidance molecules Nrp1 and Sema3A, which influence glomerular positioning in the OB ( 21525298).