SEMA4A

semaphorin 4A

Ensembl:
ENSG00000196189
UniProt:
Q9H3S1
OMIM:
607292
Synonyms:
CORD10, FLJ12287, SEMAB, SEMB

Cilia effects upon perturbation of SEMA4A

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.08) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.05) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
retinitis pigmentosa

Ciliopathy associations

  • Cone-Rod Dystrophy
  • Retinal Dystrophy/Degeneration

Subcellular localization

cilia associated gene, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Axon guidance & growth

Function

Mutations in the SEMA4A gene cause Retinitis Pigmentosa and Cone-Rod Dystrophy (PMID: 16199541).