SEMA4D

semaphorin 4D

Ensembl:
ENSG00000187764
UniProt:
Q92854
OMIM:
601866
Synonyms:
C9ORF164, CD100, COLL-4, FLJ39737, SEMAJ

Cilia effects upon perturbation of SEMA4D

Ciliogenesis screen results (5 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.94) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=667, lfc=0.53) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.76) PMID:41160700

Phenotypes

Mouse phenotype:
decreased bone mineral content, increased total body fat amount, increased circulating alkaline phosphatase level, enlarged spleen
Mouse ciliopathy phenotype:
cataract, enlarged heart

Subcellular localization

basal body, cilia, endoplasmic reticulum, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Protein processing & maturation
  • Cell migration & adhesion
  • Transition zone
  • Axon guidance & growth

Function

SEMA4D has localized in basal body ,transition zone.