SENP2

SUMO specific peptidase 2

Ensembl:
ENSG00000163904
UniProt:
Q9HC62
OMIM:
608261
Synonyms:
AXAM2, DKFZP762A2316, KIAA1331, SMT3IP2

Cilia effects upon perturbation of SENP2

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.36) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.98) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=386, lfc=-2.92) PMID:30270045

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology

Function

Overexpression of the SUMO protease SENP2 prevented ciliary localization of AC3, without affecting ciliation or cilia mainte nce ( 25908845).