SENP3

SUMO specific peptidase 3

Ensembl:
ENSG00000161956
UniProt:
Q9H4L4
OMIM:
612844
Synonyms:
DKFZP586K0919, DKFZP762A152, SMT3IP1, SSP3, ULP1

Cilia effects upon perturbation of SENP3

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.03) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=894, lfc=0.61) PMID:30270045

Phenotypes

Mouse phenotype:
increased circulating serum albumin level, abnormal behavior
Mouse ciliopathy phenotype:
increased circulating alanine transamise level

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

SUMO specific peptidase 3 (SENP3). Domi nt form of de-sumoylation enzymes in human reti (30621560)