SEPTIN4

septin 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000108387
UniProt:: O43236
OMIM:: 603696
Synonyms:: ARTS, C17ORF47, CE5B3, FLJ40121, H5, HCDCREL-2, HUCEP-7, MART, PNUTL2, SEPT4, SEPTIN-4

Cilia effects upon perturbation of SEPTIN4

Loss-of-function effect:: Shorter cilia

Subcellular localization

basal body, mitochondria

References: PMID:24317785

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

Septins are either enriched at the apical cell cortex including the ciliary bases (septin-2, -4, -6, and -7), or show axonemal staining (septin-2, -7, -9 and -11) or specifically localize to ciliary sub-compartments (septin-8 and -9)(24317785).

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