SEPTIN9

septin 9

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000184640
UniProt:: Q9UHD8
OMIM:: 604061
Synonyms:: AF17Q25, KIAA0991, MSF, MSF1, PNUTL4, SEPT9, SEPTD1

Cilia effects upon perturbation of SEPTIN9

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: Longer cilia

Subcellular localization

basal body, cilia

References: PMID:41005307, PMID:24317785

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

Septins are either enriched at the apical cell cortex including the ciliary bases (septin-2, -4, -6, and -7), or show axonemal staining (septin-2, -7, -9 and -11) or specifically localize to ciliary sub-compartments (septin-8 and -9)(24317785).

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