SESN1

Cilia effects upon perturbation of SESN1

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.94) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased mean corpuscular hemoglobin, increased aggression, abnormal optic disk morphology, increased mean corpuscular volume

Mouse ciliopathy phenotype:

persistence of hyaloid vascular system

Subcellular localization

cilia associated gene, nucleus

Functional category

• Ciliary assembly/disassembly

Function

Mutations in the SESN1 gene cause Visceral Heterotaxy (PMID: 12607115).