SFI1

SFI1 centrin binding protein

Ensembl:
ENSG00000198089
UniProt:
A8K8P3
OMIM:
612765
Synonyms:
KIAA0542, PISD, PPP1R139

Cilia effects upon perturbation of SFI1

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.49) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.38, ciliated=19.4%) PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=187, lfc=0.97) PMID:30270045

Subcellular localization

basal body, cytosol, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Saccharomyces cerevisiae Sfi1 protein , med Sfr1鈥揝fr13 in Tetrahyme , Nine of the Sfr proteins localize in unique polarized patterns surrounding the basal body (23426847).

Model organism evidence

Mus musculus (1 reference)

Centrin-POC5 inner scaffold provides distal centriole integrity for sperm flagellar assembly.

PMIDs: 41337589