SGO1

shugoshin 1

Ensembl:
ENSG00000129810
UniProt:
Q5FBB7
OMIM:
609168
Synonyms:
NY-BR-85, SGOL1

Cilia effects upon perturbation of SGO1

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, decreased circulating cholesterol level, decreased circulating hdl cholesterol level
Mouse ciliopathy phenotype:
abnormal lens morphology, increased circulating creatinine level, increased circulating bilirubin level, cataract

Subcellular localization

basal body, cilia, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Transition zone

Function

SGO-1 likely participates in constraining TAC-1 to the basal body by influencing the function of the transition zone 鈥榗iliary gate鈥