SGO1

shugoshin 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000129810
UniProt:: Q5FBB7
OMIM:: 609168
Synonyms:: NY-BR-85, SGOL1

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, decreased circulating cholesterol level, decreased circulating hdl cholesterol level

Subcellular localization

basal body, cilia, transition zone

References: PMID:38152060, PMID:37296204

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Transition zone

Function

SGO-1 likely participates in constraining TAC-1 to the basal body by influencing the function of the transition zone ‘ciliary gate’

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