SH3PXD2B

SH3 and PX domains 2B

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000174705
UniProt:
A1X283
OMIM:
613293
Synonyms:
FLJ20831, KIAA1295

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:21818352

Functional category

  • Ciliary assembly/disassembly
  • ECM & connective tissue

Function

All mice that had the Sh3pxd2bnee mutation went on to develop craniofacial dysmorphologies and subsequently otitis media, by as early as 11 days of age. Noteworthy changes in cilia and goblet cells of the middle ear mucosa in Sh3pxd2bnee mutant mice using scanning electronic microscopy found (PMID: 21818352).