SHCBP1

SHC binding and spindle associated 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000171241
UniProt:
Q8NEM2
OMIM:
611027
Synonyms:
FLJ22009, PAL

Cilia effects upon perturbation of SHCBP1

Cilia number / % ciliated:
Incrased cilia number

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.31) PMID:20393562

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:38215233

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Abrogating SHCBP1 to prevent primary cilia loss is an efficient strategy to combat AP(38215233).