SHCBP1

SHC binding and spindle associated 1

Ensembl:
ENSG00000171241
UniProt:
Q8NEM2
OMIM:
611027
Synonyms:
FLJ22009, PAL

Cilia effects upon perturbation of SHCBP1

Cilia number / % ciliated:
Incrased cilia number

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.31) PMID:20393562

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Abrogating SHCBP1 to prevent primary cilia loss is an efficient strategy to combat AP(38215233).

Model organism evidence

Mus musculus (2 references)

Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma.

Here, we report that the loss of primary cilia, mediated by SHCBP1 (SHC1 binding protein), exerted a provocative effect on AP.

PMIDs: 39312205, 38215233