SHTN1

shootin 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000187164
UniProt:
A0MZ66
OMIM:
611171
Synonyms:
KIAA1598, SHOOTIN-1, SHOOTIN1

Ciliogenesis screen results (1 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
hyperactivity, decreased lean body mass

Subcellular localization

cilia, basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Muscle contraction & physiology

Function

SHTN1 has localized in primary cilia.