SIAH2

siah E3 ubiquitin protein ligase 2

Ensembl:
ENSG00000181788
UniProt:
O43255
OMIM:
602213

Cilia effects upon perturbation of SIAH2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.80) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.89, ciliated=59.8%) PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=7.06) PMID:20393562

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Shh sig ling maintains Siah2 expression (which supports ciliogenesis in a feed-forward fashion by restraining cilium disassembly) in cerebellar granule neuron (CGN) progenitors (GNPs) in a Ras/Mapk-dependent manner. This maintains GNPs to control CGN occupancy in the germi l zone (GZ) (33082319)