SIRT2

sirtuin 2

Ensembl:
ENSG00000283100, ENSG00000068903
UniProt:
Q8IXJ6
OMIM:
604480
Synonyms:
SIR2L

Cilia effects upon perturbation of SIRT2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Decreased

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.66) PMID:41160700

Phenotypes

Mouse ciliopathy phenotype:
increased heart weight, increased circulating creatinine level

Subcellular localization

centrosome, cilia, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Neurogenesis & migration
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Regulates cell cycle progression at mitosis, replication and G1/S transition. SIRT2 acts as a sensor that links growth factor-dependent sig l transduction and primary cilia formation by regulating the cell cycle under nutrient- present conditions. Suppression leads to a cell cycle arrest and promotes formation of primary cilia, by inhibiting mTOR sig ling mainly via mTORC1 (32213867). Functions as a tubulin deacetylase. Regulates ciliogenesis and centrosome amplification. Inhibition of SIRT2 induces hyperacetylation of δΌͺ-tubulin and blocks cilia dissaembly. SIRT2 could also be responsible for aberrant centrosome amplification and polyploidy in polycystic kidney disease (24203696).

Model organism evidence

Danio rerio (2 references)

The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 conformation in primary cilia or 9 + 2 in motile cilia.

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

PMIDs: 34268305, 24203696

Drosophila (1 reference)

Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.

PMIDs: 32589908

Mus musculus (1 reference)

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

PMIDs: 24203696