SIRT6

sirtuin 6

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000077463
UniProt:
Q8N6T7
OMIM:
606211

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.07) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.77) PMID:20393562

Phenotypes

Mouse phenotype:
increased mean corpuscular hemoglobin concentration, increased circulating cholesterol level

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:28685526

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Cardiac & muscle development
  • Transcription regulation

Function

Depletion of Sirt6 suppressed the number of human nasal epithelial cell cilia, and dramatically induced HMGB1 translocation from nucleus to cytoplasm in the HNE cells. Glycyrrhizic acid (GA) and glycyrrhetinic acid (GTA) are specific chemical compounds that may be isolated from the licorice plant(28685526).