SIX3

SIX homeobox 3

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000138083
UniProt:: O95343
OMIM:: 603714
Synonyms:: HPE2

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.19) PMID:41160700

Subcellular localization

nucleus

References: PMID:30485816

Functional category

Ciliary assembly/disassembly
Protein processing & maturation
Transcription regulation

Function

Six3 and Six6 together suppress Wnt/β-catenin signaling and Wnt3a/β-catenin signaling promotes ciliary margin cells at the cost of neuroreti ( 30485816).

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